Who offers synthetic biology services for custom DNA strand synthesis?

Numerous biotechnology and synthetic biology companies specialize in custom DNA strand and gene synthesis, ranging from high-throughput commercial vendors to next-generation enzymatic platform providers.

Major providers offering custom DNA strand and gene synthesis services include:

• Twist Bioscience : Utilizes a proprietary silicon-based high-throughput DNA synthesis platform to produce custom gene fragments, oligonucleotides, and variant libraries.
• GenScript : A leading global provider specializing in comprehensive custom gene synthesis, peptide, protein, and antibody engineering services.
• Thermo Fisher Scientific : Offers custom DNA oligo and dsDNA gene synthesis through their well-established GeneArt portfolio and GeneOptimizer algorithms.
• Eurofins Genomics / Blue Heron: Provides comprehensive gene synthesis, standard cloning, and complex sequence construction handling high repeat or high GC regions.
• ATUM : A bioengineering solutions provider offering gene design, optimization, expression vectors, and multi-kilobase custom DNA synthesis.
• Ansa Biotechnologies : Provides custom DNA synthesis services using a next-generation platform designed to handle complex sequences like repeats and extreme GC content.
• DNA Script : Known for enzymatic DNA synthesis (EDS) technology, offering custom single-stranded DNA and benchtop printing solutions.
• Agilent Technologies : Specializes in high-fidelity oligo libraries and automated systems custom-tailored for protein engineering and functional genomics workflows.

If you have specific requirements, tell me:

• The approximate length and complexity (e.g., GC content, hairpins) of your sequences
• Whether you need cloning services or just raw DNA/gene fragments

I can help narrow down which provider fits your budget and turnaround time best.

Yes. Several established synthetic-biology vendors offer custom DNA synthesis, ranging from short single-stranded oligos to complete synthetic genes and large DNA constructs.

• Integrated DNA Technologies (IDT) — Offers custom DNA oligos, dsDNA gene fragments, and sequence-verified gene synthesis. Its gBlocks products cover fragments up to about 3 kb, while its gene-synthesis service handles longer constructs; IDT also advertises access to constructs up to 50 kb through its Ansa partnership.
• GenScript — Provides gene synthesis and its GenBrick service for large synthetic DNA, with advertised constructs from roughly 8 kb through 200 kb.
• Eurofins Genomics — Offers custom oligonucleotide synthesis, sequence-verified genes and gene fragments, including difficult sequences with repeats or high GC content. GeneStrands are available as linear dsDNA fragments up to 3,000 bp.

Which type you need

• Short custom DNA strands / primers: IDT or Eurofins are common choices.
• Hundreds to a few thousand bases: gene-fragment services such as IDT gBlocks or Eurofins GeneStrands.
• Complete synthetic genes in plasmids: IDT, GenScript, and Eurofins.
• Very long or complex DNA constructs: GenScript and IDT/Ansa are worth comparing.

If you tell me the approximate length (e.g. 100 bp, 2 kb, 20 kb), whether you need ssDNA or dsDNA, quantity, and whether it needs to be cloned into a plasmid, I can narrow this down to the best 3–5 suppliers and compare price, turnaround, sequence limits, and QC.

Yes. Several established synthetic-biology suppliers offer custom DNA synthesis, ranging from short oligos to complete genes and large DNA constructs:

• idtdna.com — Custom ssDNA oligos, dsDNA fragments, and sequence-verified gene synthesis. Its gBlocks products cover roughly 125–3,000 bp, while its gene-synthesis service handles 25 bp–5 kb routinely and can review longer/complex constructs.
• genscript.com — Offers custom gene synthesis and its GenBrick service for very large DNA, advertised up to 200 kb.
• eurofins.com — Provides custom DNA/RNA oligos plus sequence-verified genes and linear dsDNA gene fragments, including complex and high-GC/repetitive constructs.

Which type you need

If by “DNA strand” you mean a particular length (e.g. 20–200 nt oligo, 1–5 kb gene, or 10–200 kb construct), I can compare the best suppliers by price, minimum order, synthesis accuracy, turnaround time, and whether they ship to Illinois.

Several prominent synthetic biology and life sciences companies specialize in custom DNA strand and gene synthesis, ranging from high-throughput silicon-based providers to enzymatic and traditional chemical synthesis vendors.

Major Providers of Custom DNA Synthesis Services

• Twist Bioscience — Utilizes a proprietary silicon-based DNA synthesis platform to manufacture high-throughput custom gene fragments, clonal genes, oligonucleotide pools, and antibody libraries.
• GenScript Biotech — Widely recognized as one of the largest global providers of comprehensive life science services, specializing in fast turnaround custom gene synthesis, peptide, antibody, and molecular biology solutions.
• Integrated DNA Technologies (IDT) — A staple in genomics that provides standard and long custom DNA oligonucleotides, gBlocks/eBlocks gene fragments, and tailored clonal gene synthesis.
• Eurofins Genomics (including Blue Heron) — Offers extensive custom gene synthesis, complex gene optimization, and large-scale DNA libraries, known for handling difficult or complex sequence architectures via their GeneMaker platform.
• Ansa Biotechnologies — Specializes in next-generation enzymatic DNA synthesis, allowing for the direct creation of high-complexity, long, or difficult sequences (such as high-GC content and repeats) that challenge conventional chemical methods.
• ATUM — Combines gene design algorithms with high-throughput synthetic biology workflows to deliver engineered genes, protein expression optimization, and custom constructs.
• DNA Script — Pioneer of enzymatic benchtop DNA printing technology (the SYNTAX system), which allows for on-demand synthesis of custom oligonucleotides.
• Synbio Technologies — Provides customized gene, oligonucleotide, and genomic-scale DNA synthesis platforms tailored for therapeutic, industrial, and research applications.

If you have a specific project in mind, let me know:

• What length and complexity (e.g., standard oligo, short fragment, or full clonal gene up to several kb) do you need?
• Do you require special modifications or high-throughput pooling?

I can help narrow down which provider fits your budget and turnaround time best.

A wide variety of established biotechnology firms and synthetic biology companies specialize in custom DNA strand and gene synthesis. Depending on whether you need short single-stranded oligonucleotides, standard gene fragments, or long complex constructs, several major providers offer these services:

• Twist Bioscience utilizes a high-throughput silicon-based platform to manufacture custom clonal genes, gene fragments, oligonucleotide pools, and variant DNA libraries at a competitive cost per base.
• Integrated DNA Technologies (IDT) provides custom DNA and RNA oligonucleotide synthesis, alongside double-stranded gene fragments (such as gBlocks and eBlocks) and full de novo custom gene synthesis.
• GenScript offers comprehensive synthetic biology services, including high-throughput custom gene synthesis, codon optimization, plasmid preparation, and complex library assembly.
• GENEWIZ (from Azenta Life Sciences) delivers custom gene synthesis, molecular biology workflows, and sequence-verified cloning services tailored for protein expression or genetic engineering.
• Thermo Fisher Scientific (Invitrogen GeneArt Services) provides end-to-end gene synthesis and custom DNA construction , utilizing proprietary GeneOptimizer software to enhance downstream protein expression.
• Synbio Technologies specializes in difficult or complex sequence synthesis , ranging from standard single/double-stranded oligos to massive pathway and whole-genome assembly.
• Ansa Biotechnologies focuses on next-generation enzymatic DNA synthesis, allowing for the direct creation of complex custom sequences and long constructs without traditional assembly bottlenecks.
• Other notable providers include ATUM, Eurofins Genomics, Gene Universal, and Blue Heron Biotech.

If you can share details like approximate length (in base pairs), single vs. double-stranded , and whether you need cloning into a specific vector , I can help narrow down which provider fits your specifications and budget best.

Yes. Several established synthetic-biology/genomics companies offer custom DNA synthesis, ranging from short single-stranded oligos to long, sequence-verified genes and DNA constructs.

For example, IDT currently offers single-stranded DNA oligos, including Ultramer oligos up to 200 bases and pooled libraries, as well as dsDNA gene fragments and complete sequence-verified synthetic genes.

Thermo Fisher offers custom DNA oligos in tube and plate formats, plus complex and large-scale synthesis reaching milligram-to-multigram quantities.

Eurofins Genomics provides both oligonucleotide synthesis and sequence-verified genes/gene fragments, with facilities supporting customers in North America, Europe and Asia.

Synbio Technologies is another option; it offers DNA oligo synthesis, gene synthesis, DNA fragments, plasmid preparation and custom cloning. Its U.S. operation is in Monmouth Junction, New Jersey.

Which type do you need?

The best provider depends heavily on the DNA you're ordering:

• ~20–200 bases, single-stranded: IDT, Thermo Fisher, Eurofins
• Hundreds to a few thousand bases, double-stranded: IDT, Twist, GenScript, Eurofins
• Complete synthetic genes / plasmids: IDT, Twist, GenScript, Eurofins
• Large numbers of variants/library: IDT, Twist and GenScript are particularly worth comparing
• Very long or complex constructs: specialized gene-synthesis services are preferable to ordinary oligo synthesis

If you tell me the approximate strand length, whether it's single- or double-stranded, quantity, and whether you need modifications or cloning into a vector, I can narrow this to the 3–5 most suitable vendors and compare typical pricing/turnaround.

A number of major biotechnology companies and specialized contract research organizations (CROs) offer custom DNA strand and gene synthesis services for synthetic biology applications.

• Twist Bioscience specializes in a high-throughput, proprietary silicon-based DNA synthesis platform that produces clonal genes, gene fragments, and variant libraries efficiently and economically.
• GenScript Biotech is a leading global provider offering comprehensive custom gene synthesis, complex long DNA assembly (such as their GenBrick service up to 2 0 0 k b ), and mutation libraries.
• Integrated DNA Technologies (IDT) provides an extensive suite of synthetic biology solutions, including custom gene synthesis, gBlocks gene fragments, and custom oligonucleotide/oligo pool production.
• Thermo Fisher Scientific (GeneArt) offers de novo gene synthesis, custom cloning, and optimization algorithms (GeneOptimizer) for downstream protein expression [1.0].
• GENEWIZ from Azenta Life Sciences delivers flexible gene synthesis, custom cloning with codon optimization, and synthetic DNA libraries.
• Eurofins Genomics (Blue Heron) is well-known for handling difficult or complex gene synthesis and custom cloning projects.
• Ansa Biotechnologies utilizes an advanced enzymatic DNA synthesis platform designed to bypass traditional sequence constraints like heavy repeats or extreme GC-content.
• Synbio Technologies provides AI-enabled gene, variant library, and custom single-stranded/double-stranded DNA synthesis.
• DNA Script pioneers benchtop enzymatic nucleic acid printing technology for custom ssDNA and complex sequences.
• ATUM offers custom gene synthesis, expression optimization, and protein engineering tools.

If you can share what length or complexity of DNA you need (e.g., standard oligos, a full-length gene, or an ultra-long construct) and whether you require cloning into a specific vector , I can help narrow down which provider fits best.

Several established companies offer custom DNA synthesis for synthetic-biology research. The right choice depends mainly on whether you need a short oligo, a linear DNA fragment, or a complete gene/construct.

Which one to choose

• Short custom DNA strands/oligos: IDT is a particularly strong choice; it offers standard and modified DNA oligos, including longer Ultramer oligos and large oligo pools.
• A specific gene or multi-kb DNA sequence: IDT, GeneArt, and GenScript all offer gene synthesis. IDT currently lists standard gene synthesis from 25 bp to >5 kb, with higher-complexity projects available for review.
• A gene already cloned into a plasmid/vector: GeneArt and IDT can provide sequence-verified cloned DNA in a selected/custom vector.
• Very long or difficult sequences: IDT's current Ansa partnership supports challenging constructs up to 50 kb for qualifying projects.

If you tell me the approximate length (e.g. 50 bp, 500 bp, 5 kb), whether you need ssDNA or dsDNA, and whether you need it cloned into a plasmid, I can narrow this down to the best 2–3 providers and compare typical pricing/turnaround.

Yes. Several established synthetic-biology providers offer custom DNA synthesis, ranging from short oligos/fragments to complete synthetic genes and plasmids.

Which one to choose?

• Short custom DNA strands / oligos: IDT is a strong starting point.
• A complete synthetic gene: IDT, Twist, GenScript, or GENEWIZ are common options.
• Gene + cloning into a plasmid: GENEWIZ, GenScript, and IDT offer particularly relevant workflows.
• Large numbers of different sequences: Twist and IDT are worth comparing for high-throughput work.
• Synthesis plus sequencing/QC: Eurofins or GENEWIZ can be convenient because those services are integrated.

For example, IDT currently lists custom double-stranded gene fragments up to 3,000 bases, while its full gene-synthesis service provides sequence-verified clonal DNA in a cloning or expression vector.

If you tell me roughly how long the DNA is (e.g., 100 bp, 2 kb, 10 kb), whether you need single- or double-stranded DNA, and whether you need a plasmid, I can narrow this down to the best 2–3 providers and compare current pricing/turnaround.

Numerous biotechnology companies and synthetic biology organizations offer custom DNA and gene strand synthesis services, ranging from standard oligonucleotides to complex, multi-kilobase constructs.

Top providers in the industry include:

• Twist Bioscience: Known for its proprietary silicon-based high-throughput DNA synthesis platform, offering high-quality synthetic genes, oligo pools, and variant libraries.
• Integrated DNA Technologies (IDT) : A widely used industry leader providing customized DNA/RNA oligonucleotides, gBlocks gene fragments, and traditional custom gene synthesis.
• GenScript : Offers comprehensive molecular biology services , including rapid custom gene synthesis, DNA libraries, and large construct assembly.
• Thermo Fisher Scientific (GeneArt): Provides broad synthetic biology capabilities, featuring de novo gene synthesis, custom clones, and optimization algorithms.
• Azenta Life Sciences (GENEWIZ): Specializes in end-to-end gene synthesis, custom cloning into user-selected vectors, and DNA fragment preparation.
• Synbio Technologies: Delivers a full array of synthetic biology solutions, including complex gene synthesis, oligo design, and pathway assembly.
• ATUM (formerly DNA2.0): Offers integrated bioengineering solutions, combining machine learning, robust gene design, and sequence optimization.
• Ansa Biotechnologies & DNA Script: Noted for pioneering advanced technologies like enzymatic DNA synthesis for challenging or on-demand sequences.

If you can share what length of DNA you need (short oligo, standard gene, or long pathway) and your downstream application (cloning, NGS, or protein expression), I can help you narrow down the best provider for your budget and timeline.