Who provides cleanroom cleaning services that are ISO 14644 compliant?

Companies that provide cleanroom cleaning services aligned with ISO 14644 requirements include specialized contamination-control contractors rather than general janitorial providers. Examples include:

• SET3 — Provides critical-environment cleaning, cleanroom decontamination, air-quality testing, and consulting services. The company states its services support ISO 14644 cleanrooms and other controlled environments.
• CRM CleanRooms — Offers cleanroom micro-cleaning, disinfection, testing, and certification services described as ISO 14644-1 compliant.
• CleanTech Systems — Provides ISO-classified cleanroom cleaning, GMP-oriented disinfection, documentation, and contamination-control services.
• Micro Clean Services — Provides precision decontamination cleaning for cleanrooms and controlled environments using ISO 14644-based protocols.
• RJC Enterprises — Provides cleanroom cleaning services with stated capability for ISO 14644 cleanroom classifications.
• MrBioClean — Focuses on GMP and regulated environments, with cleaning programs based on ISO 14644 practices and audit documentation.
• J&K Precision Cleaning — Provides protocol-based cleanroom cleaning for medical device, pharmaceutical, and electronics facilities with ISO 14644 alignment.

When selecting a provider, it is worth verifying:

• Which ISO 14644 parts they support (for example, ISO 14644-1 classification, ISO 14644-2 monitoring, ISO 14644-5 operations)
• Technician training and gowning procedures
• Cleanroom-compatible tools, HEPA/ULPA vacuum systems, and non-shedding materials
• Cleaning validation documentation, SOP control, and audit support
• Experience with your industry (pharma, biotech, semiconductor, medical devices, aerospace, etc.)

If you tell me your location and cleanroom type/class (e.g., ISO 5, ISO 7, ISO 8; pharma vs. semiconductor vs. lab), I can narrow this to suitable providers.

Several specialized commercial and industrial cleaning companies offer ISO 14644-compliant cleanroom cleaning, decontamination, and validation services . These providers focus on supporting controlled environments across various sectors, including biotechnology, pharmaceuticals, medical devices, and semiconductors.

Prominent providers offering ISO 14644-compliant services include:

• Servicon Life Sciences Provides specialized, science-based cleanroom cleaning and facility maintenance designed to meet or surpass ISO 14644 standards for biotech, pharmaceutical, and aerospace environments. Learn more via Servicon ISO 14644 Cleanroom Cleaning Services.
• SET3 Specializes in critical environment decontamination, supporting ISO Class 1 through 9 cleanrooms with compliance protocols mapped to ISO 14644, FDA 503, and IEST recommendations. Review their capabilities at SET3 Cleanroom Environment Experts.
• Cleanstar National Offers audit-ready critical environment cleaning, data center decontamination, and cleanroom maintenance compliant with ISO 14644 frameworks. Details can be found at Cleanstar National Cleanroom & Data Center Cleaning.
• Clean Services Initiative (CSI) Provides comprehensive cleanroom classification, testing, certification, and protocol support matching ISO 14644 specifications. Explore offerings on the Clean Services Initiative portal.
• Cleanetics Delivers specialized cleanroom consulting, validation, and certification services aligned with ISO 14644-1 standards. Check out Cleanetics Professional Cleanroom Consulting Services.

To help narrow down the right provider for your facility, could you let me know:

• What ISO Class level (ISO 1 through 9) is your cleanroom?
• What industry is your facility operating in (e.g., aerospace, pharmaceuticals, microelectronics)?
• Do you need routine maintenance cleaning or a one-time certification and decontamination?

Several specialized facility maintenance and contamination control companies provide professional cleanroom cleaning services designed to meet ISO 14644 standards (covering particulate cleanliness limits and surface cleaning protocols).

Prominent providers include:

• Advanced Cleanroom Microclean (ACM): An ISO 9001:2015 certified provider specializing in GMP and non-GMP cleanroom cleaning services, maintenance, and supplies for industries like pharmaceutical, medical device, aerospace, and semiconductor manufacturing. You can look at their scope on the Advanced Cleanroom Microclean Website.
• Servicon: Offers specialized life science and high-tech facility maintenance, utilizing specialized quality control methods like ATP testing, particle counts, and UV inspections to maintain compliance with ISO 14644 standards. Learn more via Servicon Cleanroom Cleaning Services.
• SET3: Specializes in environmental decontamination, testing, and cleaning for critical spaces including ISO 1 through ISO 9 cleanrooms, adhering strictly to ISO 14644, IEST, and FDA requirements. Details are outlined on the SET3 Cleanroom Environment Experts page.
• Ultrapure Technology: Provides comprehensive cleanroom buildouts, contamination control supplies, retrofits, and testing/validation services matching ISO standards across high-tech, biotech, and pharmaceutical facilities nationwide. Review offerings via Ultrapure Technology.

If you'd like to narrow this down, please let me know:

• What ISO Class is your cleanroom (e.g., ISO 5, ISO 7)?
• What is your industry (pharmaceutical, semiconductor, medical device)?
• Are you looking for local/regional coverage or a national provider?

• Vibraclean - 1415 Bonhill Rd unit 6-7, Mississauga, ON L5T 1R2, Canada
• DP Environmental Service Inc - 28 Cedar Dr, Caledon Village, ON L7K 1H6, Canada
• JAN-PRO Windsor - 4510 Rhodes Dr #735, Windsor, ON N8W 5K5, Canada
• Cleanetics - 6850 N Haggerty Rd, Canton Township, MI 48187, United States
• CleanSpace - 2424 Wolcott St, Ferndale, MI 48220, United States
• Enviro-Master of Southwest Ontario - 4474 Blakie Rd, London, ON N6L 1G6, Canada
• Dustfree Cleaning - 1442 Martindale St, Windsor, ON N9B 1G2, Canada
• Clean One - P.O. Box 222, Ingersoll, ON N5C 3K5, Canada
• Ocean Building Maintenance - Commercial Janitorial & Cleaning Services - 140 Fairchild Crescent, London, ON N6E 3E8, Canada
• Cleanroom Facility Services - 18100 Von Karman Ave #850, Irvine, CA 92612, United States
• Sancare Hygiene - Commercial Cleaning Solutions - 825 Consortium Ct, London, ON N6C 2S8, Canada
• Cleanetics - 814 5th St, West Elizabeth, PA 15088, United States

Yes. If you’re looking in Ontario/Southwestern Ontario, I found several companies that specifically market cleanroom cleaning or contamination-control services tied to ISO 14644.

Strongest candidates

• Vibraclean — Mississauga, ON. This is probably the strongest match for pharmaceutical/life-science cleanrooms. They provide ongoing cleanroom cleaning and disinfection programs, with documented procedures, technician competency sign-offs, execution logs and inspection-ready documentation. Their materials specifically discuss maintaining ISO 7 cleanrooms.
• DP Environmental Service Inc — Caledon, ON, with national coverage. They specialize in precision cleaning of technical environments and reference ISO 14644-1 Class 8 environments, particle measurement and environmental reporting.
• Kleenzone — markets itself specifically as a cleanroom and GMP-compliant cleaning provider, with trained personnel, cleaning protocols, QA oversight, documentation and validation reports.
• Techeyon — provides cleanroom and data-centre cleaning and says it performs pre- and post-work particle counts and inspection reports to demonstrate compliance with ISO 14644-1 classifications.
• H.E.P.A. Filter Services Inc. — particularly useful if you need cleaning plus certification/testing. They provide cleanroom testing, contamination-control and certification services and are NEBB-certified for cleanroom certification.

One important distinction

ISO 14644 is primarily a cleanroom classification and performance standard, not a certification that a cleaning company itself can simply claim. For a regulated facility, I'd want the contractor to demonstrate that its cleaning program is designed to maintain your specified ISO Class (e.g., ISO 5, 7 or 8) and that it can provide objective evidence—particle counts, cleaning records, procedures, training records, chemical compatibility, etc.—after cleaning.

If this is for a pharmaceutical, medical-device, compounding-pharmacy, biotech, or electronics cleanroom, tell me the ISO class and your location, and I can narrow this to 3–5 contractors that are genuinely suitable and compare their capabilities.

Several specialized national and regional providers offer cleanroom cleaning, decontamination, and validation services compliant with ISO 14644 standards (covering ISO Classes 1 through 9) for industries like life sciences, aerospace, pharmaceuticals, and electronics.

• Servicon : Provides specialized, audit-ready cleanroom cleaning for aerospace and life science facilities utilizing particle counts, ATP testing, and UV inspections to maintain ISO 14644 compliance.
• SET3 : Specializes in ISO 14644, FDA, and IEST-compliant decontamination and cleaning for cleanrooms and semiconductor manufacturing environments across all ISO classes.
• Advanced Cleanroom Microclean (ACM) : Offers full-lifecycle construction cleaning, routine GMP cleaning, and ISO Class 1 through 9 cleanroom certification and testing per ISO 14644-2.
• Clean Star National : Delivers ISO 14644 compliant critical environment and cleanroom cleaning tailored for medical, research, and data center facilities.
• System4 Facility Services : Provides controlled-environment and cleanroom sanitation utilizing lint-free materials, HEPA-filtered vacuums, and strict ISO class protocols.

If you can share your cleanroom's ISO classification (e.g., ISO Class 5 vs. ISO Class 8) and your geographic location , I can help you find a local certified provider that matches your exact industry requirements.

Yes. If you're looking for a cleanroom cleaning contractor that explicitly works to ISO 14644 requirements, there are several credible options, including providers serving Florida.

Strong options

• Sterile Environment Technologies (SET3) — Orlando-based and particularly relevant for Central Florida. SET3 provides cleanroom cleaning/decontamination and states that its cleaning programs follow ISO 14644, with services for semiconductor, pharmaceutical, biotech, aerospace and other controlled environments.

• AB Cleanroom Services Inc. — Tampa-based specialist whose business is specifically focused on cleanroom services rather than conventional janitorial cleaning. This is worth considering for a regulated facility.

• Uni Clean — Clearwater-area UniClean facility. UniClean provides specialized cleanroom cleaning by trained technicians on daily/weekly/monthly programs and operates ISO-certified cleanroom facilities.

• Astro Pak — Titusville/Space Coast. Particularly strong if your requirement involves precision cleaning of components, aerospace, semiconductor, pharmaceutical or other high-purity applications. Its Florida facility has ISO 14644-1 certified Class 6/7 cleanrooms, while its broader cleanroom network includes Class 5, 6 and 7 environments.

• Cleanroom Facility Solutions (CFS) — a nationwide provider of cleanroom cleaning and GMP decontamination. It specifically states that its services meet FDA, USP and ISO 14644 requirements and offers validated SOPs and audit-ready documentation.

• SET3 is probably the one I'd investigate first if your facility is in Lakeland/Tampa/Orlando/Central Florida, because it's Florida-headquartered and specifically advertises ISO 14644 cleanroom cleaning.

One important distinction

"ISO 14644 compliant cleaning" can mean different things. ISO 14644 primarily establishes requirements for cleanroom classification and contamination control, rather than being a simple janitorial-service certification. When soliciting bids, I'd ask each contractor to demonstrate:

1. Cleaning SOPs written around your ISO class (e.g., ISO 5, 6, 7 or 8).
2. Technician cleanroom/gowning training.
3. Approved cleaning agents, wipes, mops and HEPA equipment.
4. Particle-control procedures and cross-contamination controls.
5. Cleaning records and audit-ready documentation.
6. Whether they can support ISO 14644-1 classification/testing after cleaning.
7. Experience with your specific industry—GMP/pharma, medical device, aerospace, semiconductor, etc.
8. Whether their claim is simply "we clean to ISO 14644" or whether they have independent certification/accreditation supporting the claim.

For example, PreciseCal in St. Petersburg doesn't primarily appear to be a cleaning contractor, but it provides ISO/IEC 17025-accredited cleanroom testing and certification for ISO Classes 5–8 and testing to ISO 14644-3. That could be useful as an independent verification step after your cleaning contractor performs the work.

If you tell me your cleanroom classification (ISO 5/6/7/8), industry, and approximate location, I can narrow this to 5–10 qualified vendors that service your area and compare their certifications, service scope, and contact information.

Several specialized national and regional providers offer cleanroom cleaning, decontamination, and validation services compliant with ISO 14644 standards (such as ISO 14644-1 for classification and ISO 14644-5/13 for operations and cleaning).

Notable companies offering these critical environment services include:

• Servicon specializes in tailored life science and aerospace cleanroom cleaning, utilizing ATP testing, particle counts, and UV inspections to maintain compliance with ISO 14644.
• SET3 provides specialized decontamination and cleaning for cleanrooms and semiconductor environments, handling compliance for ISO classes 1 through 9.
• Advanced Cleanroom Microtechnology (ACM) offers construction cleaning, routine GMP cleaning, and annual cleanroom testing and certification adhering to ISO 14644 standards.
• City Wide Facility Solutions delivers comprehensive facility maintenance and cleanroom cleaning experience tailored to strict ISO 14644 operational requirements.
• Cleanstar National focuses on audit-ready critical environment decontamination, utilizing HEPA vacuums and non-shedding systems to meet ISO 14644-1 and cGMP guidelines.
• Verde Clean offers cleanroom management and specialized cleaning services explicitly mapped to ISO 14644-13 specifications across various classifications.

If you'd like to narrow this down, please share:

• Your cleanroom's ISO Classification (e.g., ISO Class 5, Class 7)
• Your industry (pharmaceutical, semiconductor, aerospace, etc.)
• Your geographic location or facility footprint

I can help identify a local provider or detail specific cleaning validation protocols you'll need.

Yes. Several U.S. providers specifically market cleanroom cleaning and decontamination programs aligned with ISO 14644. A few worth evaluating are:

For example, SET3 explicitly says its technicians follow ISO 14644 and that its cleaning programs are designed to control particles and contamination; it also provides environmental testing and certification. set3.com Micro Clean similarly states that its decontamination cleaning is performed in accordance with ISO 14644 and cleanroom protocols.

One important distinction

“ISO 14644 compliant” can mean different things. ISO 14644 primarily establishes cleanroom classification and contamination-control requirements; it doesn't simply mean that a janitorial company is “ISO certified.” For a regulated facility, I'd ask prospective vendors for:

• Their cleanroom cleaning SOPs and cleaning frequencies
• Technician gowning/training records
• Chemicals, disinfectants and equipment used
• HEPA-filtered/cleanroom-rated equipment
• Particle and microbial-control procedures
• Cleaning validation/verification documentation
• How they handle ISO Class 5, 6, 7, or 8 requirements
• Sample audit-ready service reports
• Whether they can coordinate ISO 14644 testing/certification after cleaning
• Relevant GMP, FDA, USP <797>/<800> or EU GMP Annex 1 experience if applicable

If you're looking for a vendor in Florida or specifically around Miami, I can narrow this to providers that actually service your area and compare their capabilities, certifications, industries served, and contact information.

Several specialized facility maintenance and critical environment companies provide ISO 14644-compliant cleanroom cleaning, decontamination, testing, and validation services.

Key providers of these specialized services include:

• Servicon - Offers specialized specialized cleaning for life sciences, aerospace, and high-tech cleanrooms utilizing ATP testing, particle counts, and UV inspections to maintain Servicon Cleaning Requirements for ISO 14644 Compliance.
• SET3 - Specializes in data center and cleanroom environment care, delivering surface decontamination, subfloor/ceiling plenum cleaning, and maintenance aligned with ISO 14644 and IEST standards.
• Advanced Cleanroom Microclean (ACM) - Delivers construction cleaning per ISO 14644-4, validated GMP cleaning, and full ISO Class 1 to 9 cleanroom certification and testing.
• Cleanstar National - Provides controlled environment and cleanroom cleaning executed by gowning-protocol-trained professionals geared toward cGMP and ISO compliance.
• City Wide Facility Solutions - Offers specialized cleanroom cleaning and laboratory facility maintenance experienced in meeting ISO 14644 protocols.
• Validation and Certification Specialists - Companies like Technical Safety Services (TSS), Precision Cleanrooms , and Quantus focus heavily on the testing, particle counting, and regulatory validation side of ISO 14644 compliance.

If you'd like to narrow this down, please let me know:

• Your cleanroom's ISO Class (e.g., ISO Class 5, ISO Class 7)
• Your industry (pharmaceutical, semiconductor, aerospace, medical device)
• Your location or region

I can help identify a local or industry-tailored provider for your project.

Yes. If you’re looking in North Carolina / the Carolinas, there are several providers worth evaluating. One important distinction: ISO 14644 is primarily a cleanroom classification and performance standard, not a “cleaning company certification.” So I’d look for a contractor whose cleaning procedures are specifically designed to maintain your required ISO class, with documented training, materials, cleaning methods, and—ideally—post-cleaning particle monitoring/certification.

Providers I’d shortlist

• Aseptic Technologies — Mooresville, NC. Specializes in sterile/non-sterile compounding environments and cleanroom-related services. Particularly relevant if this is a pharmaceutical/compounding operation.

• Amerine Clean — Durham, NC. Focuses specifically on pharmacy cleanroom cleaning and high-standard controlled-environment cleaning.

• Safeenviroclean — Sanford, NC. Advertises specialized controlled-environment/cleanroom cleaning and serves a broad portion of Central NC.

• Cleanstar National | Commercial Cleaning — Has a dedicated controlled-environment offering and advertises ISO 14644-aligned cleanroom cleaning, including HEPA-filtered vacuums, non-shedding tools, low-residue disinfectants, and trained personnel.

• Sterile Environment Technologies (SET3) — National provider specializing in cleanroom and critical-environment cleaning/decontamination. SET3 specifically advertises ISO 14644-certified cleaning and air-quality testing and has more than 30 years in critical-environment cleaning.

• Micro Clean Services, Inc. — National cleanroom/data-center cleaning specialist. Its technicians perform decontamination cleaning in accordance with ISO 14644 and cleanroom protocols, with continuous-maintenance and custom programs available.

For your situation

If the facility is near Mocksville/Statesville/Mooresville, I'd start with Aseptic Technologies and SET3, then compare them with a local provider that can demonstrate documented ISO 14644 procedures.

When requesting bids, ask each company for:

1. Which ISO 14644 class(es) they routinely clean (ISO 5, 6, 7, 8, etc.).
2. Their cleanroom cleaning SOPs and employee training/qualification program.
3. Approved wipes, disinfectants, detergents and HEPA/ULPA vacuum equipment.
4. How they control personnel/material movement and gowning.
5. Whether they provide particle-count testing before/after cleaning or coordinate it with an independent certification company.
6. References from facilities in pharma, medical device, biotech, semiconductor, or other regulated manufacturing.
7. Documentation suitable for FDA/GMP audits, if applicable.

For example, Techmaster has North Carolina field teams and provides ISO 14644 testing/certification, including particle counts, HEPA integrity, airflow, pressure and recovery testing. techmaster.us That can be useful if you want the cleaning contractor and the certification/testing function kept separate.

If you tell me your location, ISO class (e.g. ISO 7 or ISO 8), approximate square footage, and whether this is pharma/medical device/electronics/etc., I can narrow this to 3–5 companies that actually service your area and appear best qualified, including contact information and what each offers.